Comparing single vs. multiple antibiotic doses for hip and knee replacement

This study looks at how well hip or knee replacements work. If you are already scheduled for a replacement or a revision (a second replacement), you may be able to join.

This study is testing a new way to measure how well antibiotics reach the infected area around a hip implant during a two-stage replacement surgery. If you are already planning this surgery, researchers want to see if the levels of antibiotics in the spacer are high enough to fight the infection.

This trial studies whether giving antibiotics before and/or after surgery can lower the chance of a serious joint infection after elective hip or knee replacement. It’s aimed at people at higher risk for infection.

This study is testing whether giving three different antibiotic combinations (instead of one) before surgery can better protect the good bacteria in your gut and reduce the chance of developing resistant bacteria. If you are having a joint replacement revision or similar surgery due to a suspected infection, participation might help improve how infections are treated.

This study compares two antibiotic plans for acute (early) infections around an artificial knee or hip, using a procedure to clean the joint and try to keep the implant. It may help find the best approach to control infection and then prevent it from coming back with longer-term antibiotic treatment.

This trial compares taking antibiotics by mouth versus through an IV line for people who have an infection in their hip or knee replacement. The goal is to see if oral antibiotics work just as well as IV antibiotics after surgery to clean the infection.