Comparing single vs. multiple antibiotic doses for hip and knee replacement

This study tests giving antibiotics (cefazolin and vancomycin) through a small needle into the shin bone during knee replacement surgery. The goal is to see if this way of giving antibiotics works well to prevent infection.

This study is testing a new way to measure how well antibiotics reach the infected area around a hip implant during a two-stage replacement surgery. If you are already planning this surgery, researchers want to see if the levels of antibiotics in the spacer are high enough to fight the infection.

This trial studies whether giving antibiotics before and/or after surgery can lower the chance of a serious joint infection after elective hip or knee replacement. It’s aimed at people at higher risk for infection.

This study compares two antibiotic plans for acute (early) infections around an artificial knee or hip, using a procedure to clean the joint and try to keep the implant. It may help find the best approach to control infection and then prevent it from coming back with longer-term antibiotic treatment.

This trial tests how different antibiotic combinations affect the bacteria in your gut and the risk of infection with hard-to-treat bacteria. It is for people who need surgery for a joint replacement or bone infection.

This study compares a new way of delivering antibiotics directly into the bone during hip replacement surgery versus the standard IV method. The goal is to see if this approach prevents infection just as well while potentially improving outcomes.