Antibiotics to prevent infection after hip or knee replacement
Treatments studied
Part of Hormones & metabolism, Immune system & allergy, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial studies whether giving antibiotics before and/or after surgery can lower the chance of a serious joint infection after elective hip or knee replacement. It’s aimed at people at higher risk for infection.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are planning an elective (planned) first full hip replacement (total hip) or full knee replacement (total knee)
- You are considered high-risk for joint infection, such as: BMI over 35, diabetes, current smoking, chronic kidney disease, autoimmune disease, or certain bacteria found in the nose (MRSA or MSSA)
- You can take antibiotics by mouth (oral medicine)
- You do not have an allergy to the specific antibiotic options used in the study
- You have not had a past severe stomach infection called C. difficile colitis
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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