Dual therapy with irinotecan for her2-positive colorectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of two targeted drugs (against HER2 and EGFR) plus chemotherapy for people with a specific type of advanced colorectal cancer that has spread and stopped responding to standard treatments. It aims to see if this new approach can shrink tumors or slow the cancer's growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- Your cancer must have spread to other parts of the body and be HER2-positive, with no mutations in the KRAS, NRAS, or BRAF genes.
- You must have tried and not responded to at least one prior chemotherapy that included fluorouracil, oxaliplatin, and irinotecan.
- You must be in generally good health (able to do daily activities, with adequate organ function).
- You must have at least one tumor that can be measured on scans.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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