Trastuzumab with chemo for HER2+ bile duct cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests if adding trastuzumab to standard chemotherapy can help people with advanced bile duct or gallbladder cancer that tests positive for HER2. The study aims to see if the combination works better than chemotherapy alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have gallbladder or bile duct cancer (not distal cholangiocarcinoma).
- Your cancer is HER2-positive (tested by IHC or FISH).
- You are at least 18 years old.
- You have cancer that cannot be removed by surgery or has spread.
- You have not had chemotherapy for metastatic disease before.
- You have adequate organ function (kidney, liver, blood).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This phase 3 trial tests whether adding zanidatamab (a targeted antibody) to standard chemotherapy can improve outcomes for advanced HER2-positive biliary tract cancer. If you have this type of cancer that has spread or can't be removed, and you've had little or no prior treatment, this study might be an option.
This trial tests a new drug combo—disitamab vedotin, lenvatinib, and an immunotherapy—for people with advanced bile duct cancer that has HER2 protein. It aims to see if this combination can shrink tumors or slow the disease.
This trial tests a combination of three drugs (trastuzumab rezetecan, adebrelimab, and lenvatinib) for people with advanced bile duct or gallbladder cancer that has HER2 protein on its cells. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
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