Lymphatic surgery for Alzheimer's disease (CLEAN-AD trial)
Part of Brain & nervous system, Mental health clinical trials.
This trial tests a surgical procedure that connects lymphatic vessels in the neck to help clear waste from the brain in people with moderate-to-severe Alzheimer's disease. The goal is to see if this can improve thinking and memory.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 50 and 80 years old.
- You have been diagnosed with moderate-to-severe Alzheimer's disease (a score of 10-20 on a memory test and a score of 1 or higher on a dementia rating scale).
- You have had Alzheimer's symptoms for more than 6 months.
- If you take Alzheimer's medication, you must be on a stable dose for at least 3 months before starting, or you have never taken it before.
- You have a caregiver who spends at least 8 hours per week with you and can come to all study visits.
- You are generally healthy enough for surgery and MRI scans, with no other major brain conditions, bleeding risks, or uncontrolled health problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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