Nerve blocks for pain relief after knee replacement
Part of Bones, joints & muscles, Pain clinical trials.
This study tests whether adding an extra nerve block (called IPACK) to the standard one (adductor canal block) after knee replacement improves pain control and recovery better than the standard block alone. It aims to see if the combination reduces pain and swelling and helps you regain movement faster.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are having a total knee replacement on one knee (not both at the same time, and not a repeat surgery).
- You are between 20 and 70 years old.
- You are in generally good health (classified as ASA I to III) — meaning you may have mild to moderate health conditions but are not severely ill.
- You do not have severe kidney disease, a history of irregular heartbeat or seizures, or an allergy to numbing medicines.
- You do not have nerve damage or prior blood vessel surgery in the leg being operated on, and no infection near the knee.
- You are able to receive spinal anesthesia (no blood thinners or bleeding problems).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two ways of numbing the knee after total knee replacement surgery to see which gives better pain relief. If you are having this surgery and want to manage pain without strong opioids, this trial might help you understand your options.
This trial compares two ways to numb the knee area after knee replacement surgery, both using nerve blocks. The goal is to see which approach provides better pain relief and recovery.
This trial tests a nerve block that helps manage pain after total knee replacement surgery. It may reduce the need for strong painkillers and improve your recovery. The study is for people having their first knee replacement on one knee.
This trial tests if adding extra nerve blocks (sciatic, BiFeS, or IPACK) to the usual adductor canal block can reduce pain after total knee replacement. The goal is to find a better way to manage pain and improve recovery.
This study compares two ways of numbing the knee after replacement surgery. One uses a continuous nerve block in the thigh, and the other adds an extra injection behind the knee to see if it improves pain relief and recovery.
This study compares two types of nerve blocks (pain-numbing injections around the knee) to see which provides better pain relief after knee surgery. Both are given alongside spinal anesthesia, and the goal is to improve your comfort after the operation.
Hear when a new Adductor Canal Block trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.