Vaccine with hormone therapy or chemo for advanced breast cancer
Treatments studied
Part of Cancer clinical trials.
This trial tests a vaccine (STEMVAC) given with your standard hormone therapy or chemotherapy. It is for people with advanced hormone receptor-positive, HER2-negative breast cancer who are already on certain treatments. The goal is to see if adding the vaccine can help control the cancer better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your breast cancer is hormone receptor-positive and HER2-negative or HER2-low.
- You are either on your first or second line of hormone therapy with a CDK4/6 inhibitor (at least 2 cycles) or have progressed on hormone therapy and started capecitabine chemotherapy (at least 1 cycle).
- You are willing to have up to two needle biopsies of a tumor site during the study.
- Your blood counts and organ function meet minimum levels (checked within 28 days of the vaccine).
- You do not have serious heart problems, autoimmune disease needing steroids, or a recent other cancer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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