Study of axatilimab for young people with chronic graft-versus-host disease
Treatments studied
Part of Immune system & allergy, Lungs & breathing clinical trials.
This study tests a new drug called axatilimab for children and teens with chronic graft-versus-host disease (cGVHD) that hasn't improved with standard treatments. The goal is to see if axatilimab works better than the usual care options. Participants will be randomly assigned to receive either axatilimab or one of several standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Must be between 2 and 17 years old at the time of joining the study.
- Must have active, moderate to severe chronic graft-versus-host disease (cGVHD).
- Must have tried and not responded to at least two prior treatments for cGVHD, including a steroid medicine and ruxolitinib.
- Must have had one stem cell transplant from a donor (not your own cells).
- Must not have had more than one stem cell transplant from a donor.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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