Comparing Chemo plus Radiation vs. Radiation Alone for Head and Neck Cancer
Treatments studied
Part of Cancer, Ear, nose & throat clinical trials.
This trial tests whether adding chemotherapy to radiation therapy after surgery can help prevent head and neck cancer from coming back. It is for people who have certain risk factors after their surgery but no signs of cancer spread.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with head and neck squamous cell carcinoma, a type of cancer that starts in the lining of the mouth, throat, or voice box.
- You had surgery to remove the cancer and your doctor found one or more 'intermediate-risk' features, like a larger tumor (T3 or T4) or cancer in lymph nodes.
- You are between 18 and 70 years old.
- You are in good general health, able to care for yourself (Karnofsky score above 70%).
- Your blood cell counts, liver function, and kidney function are within normal ranges as shown by recent lab tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether giving two rounds of cisplatin chemo along with radiation after surgery can help people with high-risk head and neck squamous cell carcinoma. It is for patients who have already had surgery and whose cancer showed signs of being more aggressive.
This trial tests whether giving tislelizumab (an immunotherapy) with chemotherapy before surgery works better than surgery alone for people with head and neck cancer that has not spread to lymph nodes. It's for cancers that can be removed with surgery, and the goal is to see if the pre-surgery treatment improves outcomes.
This trial looks at whether patients with head and neck squamous cell carcinoma who had a good response to chemotherapy and immunotherapy before surgery can safely have less radiation after surgery. It aims to reduce side effects while keeping treatment effective.
This trial is for people with advanced head and neck cancer who had good response to chemotherapy plus immunotherapy before surgery. It compares two different follow-up treatments: more immunotherapy or radiation therapy to help prevent cancer from coming back.
This trial studies whether adding cisplatin (a chemotherapy medicine) to radiation therapy helps people with stage III–IVA squamous cell cancer of the head and neck after they’ve had surgery. It’s meant to lower the risk of the cancer coming back.
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