Clin2
NCT03649048Possibly a fitRecruiting

Weekly low-dose or high-dose cisplatin with radiation for head and neck cancer

Locally Advanced Head and Neck Squamous Cell Carcinoma

Part of Cancer, Ear, nose & throat clinical trials.

This trial compares two cisplatin dosing schedules (weekly low-dose vs higher dose less often) given alongside radiation for certain head and neck cancers. It’s testing which schedule works well while keeping side effects manageable during planned, curative-intent radiation.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
100 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • Be 18 or older and able to sign consent paperwork
  • Have confirmed head and neck squamous cell cancer (from specific areas) or an unknown primary site
  • Be able to care for yourself fairly well (ECOG 0–2)
  • Plan to get full-course radiation with curative intent (radical treatment)
  • Have enough kidney function and blood counts to safely receive cisplatin (details checked with lab tests)
  • Meet other eligibility checks at a head-and-neck cancer team clinic and tumor board before starting treatment

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07371234Recruiting· Phase 2
Low-dose radiation and immunotherapy before surgery for head and neck cancer

This trial tests a combination of low-dose radiation and an immunotherapy drug (similar to Keytruda) given before surgery for advanced head and neck cancer. The goal is to see if this approach can shrink tumors and improve outcomes.

Guangdong
NCT06572514Recruiting· Phase 1/Phase 2
Lower radiation after chemo-immunotherapy for head and neck cancer

This trial tests if giving less radiation than usual is safe and effective for certain head and neck cancers after initial treatment with chemotherapy and immunotherapy. It aims to reduce side effects while still controlling the cancer.

Shanghai, Shanghai Municipality
NCT07780877Not yet recruiting· Phase 2
Tailored radiation after surgery for advanced head and neck cancer

This trial tests whether giving radiation therapy after surgery, adjusted based on how the cancer responds, can improve outcomes for people with advanced head and neck cancer. It may help reduce side effects while keeping the treatment effective.

Changsha, Hunan
NCT06492460Recruiting· Phase 3
Two courses of chemo-radiation after surgery for high-risk head and neck cancer

This trial tests whether giving two rounds of cisplatin chemo along with radiation after surgery can help people with high-risk head and neck squamous cell carcinoma. It is for patients who have already had surgery and whose cancer showed signs of being more aggressive.

Guangzhou, Guangdong
NCT05039606Not yet recruiting· Phase 2
Radiation with nedaplatin vs cisplatin for head and neck cancer

This trial studies whether adding nedaplatin to radiation (with cisplatin as a comparison) can improve treatment for locally advanced head and neck squamous cell carcinoma. It may help people whose tumors cannot be fully removed by surgery or who have higher-risk features after surgery.

Guiyang, Guizhou
NCT02734537Recruiting· Phase 2
Radiation with or without cisplatin after head and neck surgery

This trial studies whether adding cisplatin (a chemotherapy medicine) to radiation therapy helps people with stage III–IVA squamous cell cancer of the head and neck after they’ve had surgery. It’s meant to lower the risk of the cancer coming back.

Birmingham, Alabama

Hear when a new Locally Advanced Head and Neck Squamous Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.