Predicting response to chemoradiotherapy for head and neck cancer
Part of Cancer, Ear, nose & throat clinical trials.
This study looks at whether certain imaging tests (like MRI, CT, and PET scans) can predict how well your head and neck cancer responds to a standard treatment of radiation plus the chemotherapy drug cisplatin. If you join, researchers will use your scans and treatment results to help personalize care for future patients.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have squamous cell carcinoma (a type of head and neck cancer) in the back of the throat (oropharynx) or in the mouth (oral cavity).
- The tumor is stage T2 to T4 (meaning it's fairly large or has spread locally).
- The cancer has spread to at least one lymph node in the neck (confirmed by imaging, no biopsy needed).
- You are eligible for curative treatment with radiation plus the chemotherapy drug cisplatin (either every 3 weeks or weekly).
- You have not had radiation to the head or neck before, and you have no other recent invasive cancer (except a very early melanoma).
- You are not pregnant or breastfeeding, and you don't have allergies to contrast dyes used in scans.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether adding chemotherapy to radiation therapy after surgery can help prevent head and neck cancer from coming back. It is for people who have certain risk factors after their surgery but no signs of cancer spread.
This study tests an optimized plan for treating squamous cell cancer in the head and neck area using curative treatment that includes chemotherapy with cisplatin plus radiation after surgery. It may help doctors improve early management and outcomes for people eligible for this standard approach.
This study tests whether delaying radiation therapy can help doctors learn more from MRI scans and immune system changes in patients with head and neck cancer. This could lead to better treatment decisions.
This trial tests whether giving two rounds of cisplatin chemo along with radiation after surgery can help people with high-risk head and neck squamous cell carcinoma. It is for patients who have already had surgery and whose cancer showed signs of being more aggressive.
This trial is studying how MRI images can help predict response to a combination of chemotherapy and immunotherapy before surgery for head and neck cancer. It aims to improve treatment planning for patients with this type of cancer.
This study looks at using a special scan (F-MISO-PET) to see areas of low oxygen in head and neck cancer. The radiation dose is then customized to give higher doses to those low-oxygen areas, which may improve the chance of controlling the tumor.
Hear when a new Squamous Cell Cancer of Head and Neck (SCCHN) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.