Combination therapy for advanced AFP-producing gastric cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus a targeted therapy (apatinib) and a chemotherapy drug (irinotecan hydrochloride) for people with a rare type of advanced stomach cancer called AFP-producing gastric cancer. It is for patients whose cancer did not respond to previous immunotherapy combined with chemotherapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery or has spread to other parts of the body.
- Your blood test shows a high level of alpha-fetoprotein (AFP) – above 20 ng/mL.
- You have already tried a PD-1 inhibitor (like immunotherapy) combined with chemotherapy, and your cancer did not respond or came back.
- You are in fairly good health (ECOG 0-1) and doctors expect you to live at least 3 more months.
- Your liver, kidney, and blood cell counts are within a safe range (your doctor will check these).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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