Sivelestat for organ protection after aortic dissection surgery
Treatments studied
Part of Heart & circulation clinical trials.
This study tests whether a drug called sivelestat can help protect your organs after surgery for a type A aortic dissection. It may reduce inflammation and improve recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have been diagnosed with acute type A aortic dissection and are scheduled for surgery.
- You are not pregnant or breastfeeding.
- You do not have severe liver or kidney disease that requires special treatment.
- You do not have COPD or asthma, and you are not on long-term steroids or immune-suppressing drugs.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new surgical method (XJ-Procedure) for people with an acute tear in the upper part of the main artery from the heart (type A aortic dissection). It may offer a safer option for those needing 'Sun's procedure' surgery.
This study tests if a simple arm-leg blood pressure cuff procedure before surgery can help protect organs during emergency repair of a torn aorta. It may reduce complications and improve recovery after surgery.
This trial tests whether ketorolac, a common pain reliever, can improve outcomes and prognosis for people having emergency surgery for a type A aortic dissection. If you are eligible and choose to join, you may receive ketorolac in addition to standard care.
This study tests whether a drug called sivelestat can protect your lungs and other organs during emergency surgery for a very serious aortic tear. If you qualify, you would receive the drug or a placebo right before and after surgery.
This trial tests whether taking a cholesterol-lowering medicine (a statin) after certain aortic surgeries can reduce harmful changes in the heart and other organs. You might benefit by lowering the risk of ongoing damage after your acute aortic condition and surgery.
This trial tests whether two anti-inflammatory drugs, ulinastatin and thymosin α1, can help protect your immune system and organs after emergency surgery for a torn aorta (aortic dissection). If you qualify and take part, you may receive these medications in addition to standard care.
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