Fluoxetine plus immunotherapy for advanced liver cancer with depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help treat advanced liver or bile duct cancer in people who also have depression or anxiety. You must not have received any prior cancer treatment and be ready to start immunotherapy as your first therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced liver or bile duct cancer (hepatocellular carcinoma or cholangiocarcinoma) that has spread or can't be removed with surgery.
- You haven't had any cancer treatment yet, and your doctor plans to start you on immunotherapy (a type of drug that helps your immune system fight cancer).
- You feel down or anxious most of the time, with a score that suggests depression or anxiety on a standard screening questionnaire (PHQ-9 or GAD-7).
- You are able to swallow pills.
- Your blood counts and liver/kidney function tests are within certain safe limits (your doctor will check these).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a combination of chemotherapy (FOLFOX) plus two immunotherapy drugs (Camrelizumab and Apatinib) works better when given directly into the liver artery (HAIC) versus through a vein. It's for people with advanced liver cancer who haven't had other treatments yet.
This trial tests a combination of targeted radiation (photon radiotherapy) with two immunotherapy drugs (tremelimumab and durvalumab) for people with intermediate or advanced liver cancer that can't be surgically removed. The goal is to see if this combination can shrink tumors and improve outcomes.
This trial studies whether a structured talking therapy called CBT (cognitive behavioral therapy) can reduce anxiety and depression in people living with liver cancer. If you feel significantly anxious or depressed, the program may help you cope better.
This trial tests a combination of immunotherapy (anti-PD-1/PD-L1) and an anti-VEGF drug for people with advanced hepatocellular carcinoma (HCC), a type of liver cancer that cannot be removed by surgery or has spread. The goal is to see if these drugs can shrink tumors or slow the cancer's growth.
This trial tests whether changing the bacteria in your gut (with a probiotic) can help your current immunotherapy work better if your liver cancer has been growing. It's for people with advanced liver cancer who will continue their same immunotherapy despite the cancer progressing.
This trial tests a combination of targeted radiation, an immunotherapy drug (PD-L1 inhibitor), and an anti-VEGF drug to shrink tumors and improve outcomes for people with advanced hepatocellular carcinoma that cannot be surgically removed.
Hear when a new Anxiety Disorders trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.