Fluoxetine plus immunotherapy for advanced liver cancer with depression
Treatments studied
Part of Mental health clinical trials.
This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help treat advanced liver or bile duct cancer in people who also have depression or anxiety. You must not have received any prior cancer treatment and be ready to start immunotherapy as your first therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced liver or bile duct cancer (hepatocellular carcinoma or cholangiocarcinoma) that has spread or can't be removed with surgery.
- You haven't had any cancer treatment yet, and your doctor plans to start you on immunotherapy (a type of drug that helps your immune system fight cancer).
- You feel down or anxious most of the time, with a score that suggests depression or anxiety on a standard screening questionnaire (PHQ-9 or GAD-7).
- You are able to swallow pills.
- Your blood counts and liver/kidney function tests are within certain safe limits (your doctor will check these).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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