Clin2
NCT07182708Possibly a fitNot yet recruiting

Targeted therapy before surgery for EGFR-mutated lung cancer

NSCLC (Non-small Cell Lung Cancer)EGFR Activating MutationResectable Lung Non-Small Cell Carcinoma

Treatments studied

Part of Cancer, Lungs & breathing clinical trials.

This trial tests a combination of two targeted drugs (firmonertinib and bevacizumab) given before surgery for people with early-stage, EGFR-mutated lung cancer. The goal is to shrink the tumor and improve the chances of successful surgery.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
62 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be at least 18 years old.
  • You must have a type of lung cancer called non-small cell lung cancer that has an EGFR mutation.
  • Your cancer must be at stage II, IIIA, or IIIB, and your doctor plans to remove it with surgery.
  • You must be in generally good health, able to care for yourself, and have adequate organ function.
  • You must not have had any previous treatment for this cancer (no chemotherapy, radiation, or surgery).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07742332Recruiting· Phase 2
Targeted therapy before surgery for EGFR-mutant lung cancer

This trial tests a combination of two targeted medicines (befotertinib and bevacizumab) before surgery for people with EGFR-mutant non-small cell lung cancer that cannot be removed right away. The goal is to see if this treatment can shrink the tumor and improve surgery outcomes.

Shanghai, Shanghai Municipality
NCT07807722Not yet recruiting· Phase 2
Combination therapy before surgery for early-stage EGFR-mutant lung cancer

This study tests whether combining an EGFR-targeted pill with chemotherapy before surgery can shrink or control early-stage non-small cell lung cancer that has an EGFR mutation. It aims to improve outcomes for patients whose tumors can be removed surgically.

Wuhan, Hubei
NCT07329322Recruiting· Phase 2
Drug combo before surgery for EGFR-mutated lung cancer

This trial tests a combination of two targeted drugs (sacituzumab tirumotecan and osimertinib) before surgery for people with a specific type of lung cancer (EGFR-mutated). The goal is to see if the drugs can shrink the tumor enough to improve surgery results.

Beijing
NCT06956001Recruiting· Phase 3
Testing firmanertinib vs chemo for first-line lung cancer with specific EGFR mutations

This trial compares a new targeted therapy pill (firmanertinib) to standard chemotherapy in people with advanced non-small cell lung cancer whose tumors have a specific EGFR mutation (PACC or L861Q). If you haven't had treatment for advanced disease and your cancer matches these mutations, this study may offer a more convenient oral option.

Beijing, Beijing Municipality
NCT06890182Not yet recruiting· Phase 2
Targeted therapy plus chemotherapy before surgery for EGFR-mutated lung cancer

This trial tests a targeted therapy (firmonertinib) combined with standard chemotherapy before surgery, to see if it can shrink tumors and improve outcomes for people with early-stage lung cancer that has a specific EGFR gene change.

NCT07622706Not yet recruiting· Phase 2
Firmonertinib before and after surgery for EGFR-mutated lung cancer

This trial tests a targeted therapy pill (firmonertinib) given before and after surgery for stage II–III lung adenocarcinoma that has an EGFR mutation. The goal is to see if this approach can shrink the tumor before surgery and reduce the chance of cancer coming back.

Hear when a new EGFR Activating Mutation trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.