Clot-busting drug through artery for medium-vessel stroke
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests a clot-busting drug given directly into the arteries of the brain for people who have had a stroke due to a blockage in a medium-sized artery. It aims to see if this treatment can help improve recovery when started up to 72 hours after symptoms begin.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have a blockage or severe narrowing in a medium-sized brain artery, confirmed by a scan.
- You must start treatment within 24 to 72 hours of your stroke, depending on your specific brain scan results.
- Your stroke symptoms must be moderate to moderately severe (NIH Stroke Scale score 5–25 or 3–4 with disabling problems).
- You must be able to give informed consent and have no other serious medical conditions that might interfere.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new clot-busting medicine called tenecteplase, given directly into the blood vessel in the brain, to treat strokes caused by a blockage in a medium-sized artery. The goal is to see if it can help restore blood flow and reduce disability, especially for patients who can be treated within 24 hours of stroke onset.
This trial tests a clot-busting drug called tenecteplase given directly into the brain artery for people having a moderate stroke caused by a blockage in a medium-sized blood vessel. The goal is to see if it helps improve recovery when given within 24 hours of stroke symptoms starting.
This study tests a drug injected directly into the blocked brain artery through a catheter (intra-arterial thrombolysis) to treat acute strokes caused by medium-sized vessel blockages. It may help reopen the vessel faster and reduce disability, even if you arrive up to 24 hours after symptoms began.
This trial tests if removing clots from smaller arteries in the brain (not the main ones) helps people who had a stroke and can't get standard clot-busting medicine. It compares clot removal to usual care for strokes caused by these medium-sized vessel blockages.
This trial tests whether giving a clot-busting medication (tenecteplase) intravenously before mechanical thrombectomy—a procedure to physically remove a large blood clot from the brain—improves recovery better than thrombectomy alone in patients with large ischemic strokes.
This study looks at how well a procedure to remove blood clots from medium-sized brain arteries works for people who have had a severe stroke. It may help improve recovery by treating blockages that are not in the largest arteries.
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