Testing emapalumab for gut inflammation in APECED
Treatments studied
Part of Hormones & metabolism, Immune system & allergy clinical trials.
This trial tests a drug called emapalumab to treat chronic gut inflammation (enteritis) in people with APECED, a rare immune disorder. It aims to see if the drug can help when other treatments haven't worked.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 2 and 75 years old.
- You have APECED (confirmed by genetic testing or a doctor) and chronic gut inflammation that has lasted more than 6 months.
- You are already in another NIH study (protocol 11-I-0187) about fungal infections.
- You have not tried other treatments for gut inflammation, or those treatments did not help.
- You are willing to take antiviral medicines (like acyclovir) to prevent herpes virus reactivation.
- You are willing to use effective birth control if you or your partner could become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a pill called upadacitinib (a JAK inhibitor) in people with eosinophilic esophagitis (EoE) that hasn't improved with swallowed steroids. It aims to see if the drug can reduce inflammation and symptoms in the esophagus when added to your current steroid treatment.
This trial tests a medicine called efgartigimod to treat autoimmune encephalitis (AIE)—a rare condition where the immune system attacks the brain. The study enrolls children 12+ and adults to see if this drug can reduce symptoms and help recovery.
This study tests a drug called emapalumab to help people whose blood counts stay low for weeks after CAR T-cell therapy for certain types of lymphoma. The goal is to see if the drug can help the body recover normal blood cell production.
This study tests whether adding palmitoylethanolamide (a natural compound that may help reduce inflammation) to standard treatment can improve symptoms for people with active mild-to-moderate ulcerative colitis who are not responding well to current medications.
This trial tests if etrasimod can prevent pouchitis, which is inflammation of the surgically created internal pouch, in people who have had their colon removed due to ulcerative colitis. If you are at high risk for pouchitis or have had only one episode, this study may help keep your pouch healthy.
This study tests an oral medication (EC-18) for moderate to severe atopic dermatitis (eczema) to see if it can improve symptoms like itching and skin rash. It may be an option for people whose eczema is not controlled by topical treatments.
Hear when a new Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Enteritis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.