Testing emapalumab for gut inflammation in APECED
Treatments studied
Part of Hormones & metabolism, Immune system & allergy clinical trials.
This trial tests a drug called emapalumab to treat chronic gut inflammation (enteritis) in people with APECED, a rare immune disorder. It aims to see if the drug can help when other treatments haven't worked.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 2 and 75 years old.
- You have APECED (confirmed by genetic testing or a doctor) and chronic gut inflammation that has lasted more than 6 months.
- You are already in another NIH study (protocol 11-I-0187) about fungal infections.
- You have not tried other treatments for gut inflammation, or those treatments did not help.
- You are willing to take antiviral medicines (like acyclovir) to prevent herpes virus reactivation.
- You are willing to use effective birth control if you or your partner could become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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