Upadacitinib for eosinophilic esophagitis resistant to steroids
Treatments studied
Part of Blood & lymphatic, Digestive system, Immune system & allergy clinical trials.
This study tests whether a medication called upadacitinib can help people with eosinophilic esophagitis (a condition where too many white blood cells called eosinophils build up in the food tube) who are not getting better with their current steroid treatment. The medication works by reducing inflammation in the esophagus.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–65 years
- Confirmed diagnosis of eosinophilic esophagitis and currently taking topical steroid medication (budesonide or fluticasone) for at least 8 weeks
- Active symptoms like trouble swallowing, heartburn, chest pain, or abdominal pain in the past 4 weeks, confirmed by endoscopy showing high eosinophil counts despite steroid treatment
- Able to swallow pills and willing to keep taking all current EoE medications unchanged throughout the study
- No history of shingles, herpes simplex, HIV, tuberculosis, recent infections, or certain heart/blood clot conditions
- Not pregnant, not planning pregnancy, and willing to use non-estrogen birth control if of childbearing age
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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