Clin2
NCT07214311Possibly a fitRecruiting

Preventing repeat knee infection after joint-saving surgery

Prosthetic-joint Infection

Part of Bones, joints & muscles, Infections clinical trials.

This trial tests a new medicine called PLG0206 to help prevent a knee infection from coming back after a procedure to clean the joint while keeping the artificial knee in place. If you qualify, you'll receive the study medicine or a placebo along with standard antibiotics.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2/Phase 3
Enrollment
240 people
Ages
18 years to 85 years
Study type
Interventional

Who can take part

  • You are between 18 and 85 years old.
  • You have a suspected or confirmed infection in your artificial knee joint.
  • The artificial knee is firmly in place and the surrounding tissue is in good condition (no open sinus tract).
  • You are planning to have a single DAIR procedure (clean out the joint, keep the implant, and use antibiotics).
  • If you could become pregnant, you agree to use birth control during the trial.
  • You are not expected to need antibiotics for more than 6 months after the procedure.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06636669Enrolling by invitation· Phase 4
Probiotics to prevent repeat joint infection after replacement surgery

This trial tests whether taking probiotics can help prevent another infection in people who have had a hip or knee replacement that became infected. If you are scheduled for revision surgery due to an infection, this study may be a good fit.

Boston, Massachusetts
NCT02801253Recruiting
Study of infections around hip, knee, or shoulder implants

This study follows people who have an infection around a hip, knee, or shoulder implant (prosthesis). It uses standard infection tests (like cultures and blood tests) to confirm the diagnosis and better understand this problem after surgery.

Paris, Île-de-France Region
NCT06919913Recruiting
Probiotics for joint infection surgery

This study tests if taking probiotics before and after surgery can help your immune system fight infection in a hip or knee replacement. You would be given a probiotic or a placebo alongside your standard treatment.

New York, New York
NCT05640336Enrolling by invitation
Antibiotics for early knee or hip joint infections after surgery

This study compares two antibiotic plans for acute (early) infections around an artificial knee or hip, using a procedure to clean the joint and try to keep the implant. It may help find the best approach to control infection and then prevent it from coming back with longer-term antibiotic treatment.

Jacksonville, Florida
NCT07599865Recruiting· Phase 2
Bubble study for knee infection after joint replacement

This trial tests if a contrast agent used in ultrasound can help surgeons see pockets of infection around knee implants during revision surgery. It may help doctors do a better job cleaning out the infection.

Philadelphia, Pennsylvania
NCT07698002Not yet recruiting· Phase 2/Phase 3
Phage therapy and antibiotics for joint infections

This study tests whether adding a treatment with special viruses (called phages) to standard antibiotic care can help clear a joint infection more effectively after surgery. The goal is to improve your chances of keeping the artificial hip or knee and avoid the need for more procedures.

Ottawa

Hear when a new Prosthetic Joint Infection trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.