Melatonin for a rare epilepsy with sleep-related brain spikes
Treatments studied
Part of Brain & nervous system clinical trials.
This study tests whether melatonin can help reduce abnormal brain activity during sleep in children with a rare epilepsy called DEE-SWAS. It may offer a new treatment option for managing seizures and developmental problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a diagnosis of a specific epilepsy syndrome called DEE-SWAS (confirmed by a pediatric neurologist or epilepsy specialist).
- You must have had developmental delays or loss of skills in at least one area (such as movement, language, or thinking).
- Your overnight sleep EEG must show that more than half of your brain wave activity during sleep is abnormal (spike-wave index of 50% or higher).
- You cannot have serious heart, lung, or liver problems, or be allergic to melatonin or certain other medications.
- Participants who have started menstruating must not be pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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