Esketamine for teens with severe depression and suicidal thoughts
Treatments studied
Part of Mental health clinical trials.
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Diagnosed with major depression (confirmed by a doctor)
- Severe suicidal thoughts at the start of the study
- Depression symptoms that are moderate to severe
- Doctor says you need to be in the hospital right now for safety
- Generally healthy based on physical exam and heart test
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a medicine called ketamine (given as a shot under the skin) to see if it helps reduce depression and suicidal thoughts in teenagers. It is for teens aged 12 to 19 who are already getting treatment for depression but still have serious suicidal thoughts or have attempted suicide.
This study tests whether esketamine, a nasal spray for depression, can help adults whose depression has not improved with at least two other antidepressants. Participants continue their current treatment while receiving esketamine.
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