Body chemicals and brain changes after back surgery
Part of Bones, joints & muscles clinical trials.
This trial studies how certain chemicals in your body and brain change after a type of back surgery called endoscopic decompression. If you have lumbar spinal stenosis (narrowing of the spine) or a herniated disc and are scheduled for this surgery, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 40 and 90 years old, or between 18 and 40 with a slipped disc (herniated disc) in your lower back.
- You have a recent MRI scan of your lower back showing either spinal narrowing (stenosis) or a herniated disc.
- You are scheduled for a minimally invasive (endoscopic) surgical treatment for your condition.
- You do not have serious inflammatory diseases (like rheumatoid arthritis), uncontrolled diabetes, heart problems, or recent neurological issues.
- You are not pregnant or nursing, and have not had previous spine surgery at the same level in your lower back.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares outcomes after decompression surgery for one affected area in the lower back, with and without adding spinal fusion. It may help patients avoid unnecessary extra surgery—or ensure fusion is used when it’s needed.
This trial tests a less invasive spinal surgery using an endoscope (a small camera) to treat certain spine problems without fusing bones together, which may help you recover faster. It is for adults with specific types of back or leg pain from conditions like a failed previous fusion, a slipped vertebra, or a curved spine with narrowing.
This study looks at recovery after planned (elective) surgery for common lower-back (“lumbar”) spine problems like slipped discs, disc bulges, and narrowing of the spinal canal. You may be asked to complete online questionnaires, and the study uses your answers to understand symptoms and outcomes after surgery.
This study looks at how muscle degeneration relates to nerve-related symptoms in people with chronic low back pain. You may be eligible if you’ve tried non-surgical care but still need surgery to relieve nerve pressure.
This study is tracking how active people are before and after surgery for lumbar spinal stenosis (a common cause of back and leg pain in older adults). It aims to see if activity monitoring can help improve recovery.
This study looks at a newer, less invasive type of back surgery called endoscopic laminotomy. It may help people with lumbar spinal stenosis (narrowing of the spinal canal) who still have leg or back pain after trying physical therapy and pain medicines for at least 3 months.
Hear when a new Spinal Stenosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.