Cilostazol to prevent brain damage after aneurysm surgery
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests if a medicine called cilostazol can reduce the risk of a delayed shortage of blood in the brain after having a bleeding aneurysm treated. It aims to improve recovery by preventing a common complication called delayed cerebral ischemia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You had a brain hemorrhage from a burst aneurysm, and you had surgery (endovascular coiling or surgical clipping) within 72 hours of symptoms starting.
- Your aneurysm was treated successfully, and there is no rebleeding on a CT scan within 6 hours after surgery.
- You are in good general health before the hemorrhage, with no serious disability or major heart, liver, or kidney problems.
- You are not pregnant or breastfeeding, and you have no allergies to cilostazol or risk of bleeding problems.
- You are willing to sign a consent form and follow the study rules.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether starting blood pressure lowering treatment earlier after aneurysm repair improves recovery. If you've recently had a bleeding brain aneurysm treated, this may help reduce complications.
This trial tests whether adding a drug called cilostazol to standard care (nimodipine) helps people recover better after a type of stroke caused by a bleeding brain aneurysm. It may help prevent complications like narrowing of blood vessels in the brain.
This study tests a blood-thinning medicine called tirofiban to see if it helps reduce delayed brain damage after a type of stroke from a bleeding brain aneurysm. It is for people who have already had their aneurysm fixed with coiling, and the medicine is given soon after.
This study tests a simple, non-invasive technique called remote ischemic preconditioning to help prevent lack of blood flow to the brain after a bleeding brain aneurysm. It works by repeatedly inflating and deflating a blood pressure cuff on an arm or leg, which may help protect the brain from further damage.
This trial tests whether placing a small drain in the lower back and giving a clot-dissolving medicine (urokinase) into the fluid around the brain can help people recover from a severe bleeding stroke caused by a brain aneurysm. It is for patients who are treated quickly after the bleed.
This trial tests a safe, non-invasive treatment called remote ischemic conditioning (using a blood pressure cuff on your leg) to see if it helps brain recovery after aneurysm surgery. It might reduce secondary damage and improve outcomes.
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