Clin2
NCT07262723Possibly a fitNot yet recruiting

Levosimendan for severe heart failure symptoms

Acute Decompensated Heart Failure (ADHF)

Treatments studied

Part of Heart & circulation clinical trials.

This trial tests a medicine called levosimendan to see if it helps people with severe heart failure who still feel breathless at rest despite standard treatment. It may improve heart function and reduce symptoms.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2/Phase 3
Enrollment
332 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are over 18 years old
  • You have heart failure with a weakened heart (ejection fraction less than 40%)
  • You are currently in the hospital for heart failure symptoms
  • You still feel short of breath at rest even after receiving IV diuretics (water pills)
  • You have not had heart surgery, a heart device, or a heart procedure in the last 3 months
  • You do not have severe kidney, liver, or lung disease, or active infection

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT04020263Recruiting· Phase 3
Levosimendan early treatment vs placebo for cardiogenic shock

This study tests whether giving levosimendan early (a heart-strengthening medicine) improves outcomes compared with placebo, on top of standard inotropic support, in people with cardiogenic shock. It mainly looks at whether patients have fewer serious complications or deaths.

Strasbourg, Bas-Rhin
NCT07105202Recruiting· Phase 4
Shorter weaning from ventilator with levosimendan

This study tests if a heart medication called levosimendan helps people get off the breathing machine (ventilator) faster. It's for people who have been on a ventilator for more than 48 hours and have already tried and failed to breathe on their own.

Arnhem, Gelderland
NCT06993584Not yet recruiting
How the heart drug levosimendan works in adults

This study looks at how the drug levosimendan, which helps the heart pump better during shock, works in the body of adults in the ICU. By measuring drug levels in the blood, researchers hope to find the best dosing for each person.

Amiens
NCT05271214Recruiting
Testing conservative care for people with failing heart pumps

This trial is studying a non-surgical (conservative) treatment approach for people being considered for a left ventricular assist device (LVAD). It may help some patients who are too sick or unable to tolerate standard heart failure medicines, but it will only match people with specific heart function and health-test results.

Tel Aviv
NCT04768322Recruiting
LVAD versus standard heart failure medicines in advanced patients

This trial compares an LVAD device (a pump placed in the chest) plus medicines versus medicines alone for people with advanced, end-stage heart failure. It aims to see which approach works better to help patients live and stay out of the hospital.

Besançon
NCT05276219Recruiting· Phase 4
Vasodilators or diuretics for acute heart failure

This trial compares two treatments for sudden heart failure symptoms like severe shortness of breath. It aims to see whether opening blood vessels or using a water pill works better to relieve congestion and improve breathing.

Copenhagen, Copenhagen

Hear when a new Acute Decompensated Heart Failure (ADHF) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.