Study of emavusertib with zanubrutinib for CLL and other B-cell cancers
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial combines an experimental drug, emavusertib, with zanubrutinib (a standard targeted therapy) for people with chronic lymphocytic leukemia (CLL) or other B-cell cancers. It aims to see if the combination can improve response in patients who still have some disease despite taking zanubrutinib or whose disease has worsened on it.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- You must have CLL (confirmed by your doctor) and your disease must be measurable on scans or tests.
- You must be currently taking zanubrutinib (a targeted cancer pill).
- You must have either: some remaining disease (even if on zanubrutinib) OR your CLL has worsened on zanubrutinib and you have no other standard options.
- You cannot have certain high-risk CLL features (like TP53 mutations or 17p deletion) if you are in the first group.
- You must be willing to take oral medications and have a contrast CT scan.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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