Clin2
NCT07276997Likely a fitRecruiting

Study of Icalcaprant for major depressive disorder

Major Depressive Disorder

Part of Mental health clinical trials.

This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
195 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You have been diagnosed with major depressive disorder (MDD) without psychotic features.
  • Your body mass index (BMI) is between 18 and 35.
  • Your current major depressive episode started at least 4 weeks ago but within the last 6 months.
  • You have not failed 3 or more antidepressant treatments for this episode.
  • You have no known allergy to icalcaprant or similar drugs.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07772531Not yet recruiting· Phase 2
Study of a new drug for major depressive disorder

This study tests a new medication called BMS-986511 for adults with major depressive disorder. It aims to see if the drug can help relieve depression symptoms more effectively than a placebo.

Phoenix, Arizona
NCT06580041Enrolling by invitation· Phase 4
Precision treatment for major depression

This trial tests a personalized approach to treating major depressive disorder using assessments and brain imaging to match you with the best therapy. It aims to improve outcomes by tailoring care to your specific needs.

San Francisco, California
NCT06963021Recruiting· Phase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment

This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.

Chino, California
NCT05136755Recruiting· Phase 2
NMDA treatment for depression that did not improve

This trial studies an NMDA-based treatment for people with major depressive disorder who did not respond to at least one antidepressant. It may help by changing brain signaling linked to depression symptoms.

Taichung
NCT07003997Recruiting· Phase 2
Targeting inflammation for depression treatment

This trial tests whether a medication that targets inflammation in the body can help relieve depression symptoms. You will have blood tests and an MRI to see how your brain and immune system respond.

Atlanta, Georgia
NCT05017311Recruiting· Phase 4
Testing a depression medication plan using symptom predictions

This Phase 4 study tests an “optimized” medication approach for adults with major depressive disorder (unipolar depression) based on how you respond over time. It may help your care team choose treatments more effectively and reduce trial-and-error.

Calgary, Alberta

Hear when a new Major Depressive Disorder trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.