Alternating steroid and platelet-rich plasma injections for mouth stiffness
Treatments studied
Part of Brain & nervous system, Mouth & dental clinical trials.
This study tests a weekly treatment that alternates between two injections—a steroid (triamcinolone) and platelet-rich plasma (PRP, made from your own blood)—to help reduce mouth stiffness and burning caused by oral submucous fibrosis. It may improve your ability to open your mouth and ease discomfort.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a confirmed diagnosis of oral submucous fibrosis (stiffness and burning in the mouth) that is stage 2, 3, or 4.
- You need to be between 18 and 65 years old.
- Your mouth opening should be 30 mm or less (about the width of two fingers).
- You should have a burning sensation in your mouth that rates 3 or higher on a 0–10 scale.
- You must be willing to attend weekly therapy sessions and follow the treatment plan.
- You cannot have had certain prior mouth treatments (like platelet-rich plasma or steroids) in the last 6 months, and you must not have untreated serious health issues like uncontrolled diabetes or bleeding disorders.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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