Testing capivasertib with hormone therapy for advanced breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests a new oral drug called capivasertib combined with standard hormone therapy for people with advanced breast cancer that is HR-positive and HER2-negative. It is for those whose cancer has progressed on previous hormone therapy and who have a specific gene change (PIK3CA, AKT1, or PTEN).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult (18 or older) with a type of breast cancer called HR-positive, HER2-negative.
- Your cancer has gotten worse while on hormone therapy or within 12 months of finishing it.
- You have a specific gene change (PIK3CA, AKT1, or PTEN) in your tumor.
- Your cancer has spread to other parts of the body or is locally advanced and cannot be removed with surgery.
- You are in generally good health (able to do daily activities) and have not had more than 2 types of hormone therapy or 1 type of chemotherapy for advanced breast cancer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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