Skin cell study for COL5A mutation and aortic aneurysm
Part of Heart & circulation clinical trials.
This trial collects a small skin sample from adults with a COL5A gene mutation and thoracic aortic aneurysm. Researchers study the skin cells to better understand the condition and explore potential treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a confirmed mutation in the COL5A gene.
- You are willing to sign a consent form.
- You have not taken corticosteroids, steroids, or fluoroquinolone antibiotics in the last 6 months.
- You are not on blood-thinning medications like warfarin or anticoagulants.
- You have no history of keloid scarring or allergy to anesthesia.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at skin cells (fibroblasts) from people with Marfan syndrome or other genetic conditions that cause thoracic aortic aneurysms. The goal is to understand how these cells behave, which may help improve future treatments.
This study looks at people with a mutation in the COL4A1 or COL4A2 genes, which can cause problems in small blood vessels throughout the body. It aims to learn more about the condition and may also include family members who carry the mutation or who can serve as healthy controls.
This trial is for people with inherited (family-run) aortic enlargement or aneurysm caused by a specific DNA gene change. It uses genetic information to guide more precise care, which may help tailor monitoring and treatment for you and your family.
This study collects a small skin sample (biopsy) from people with ALS, those who carry an ALS gene mutation but have no symptoms, and healthy volunteers. The sample is used to grow cells in the lab to better understand how ALS develops.
This trial collects skin samples from people with scleroderma and from healthy volunteers undergoing plastic surgery. Researchers will study the genes in skin cells to better understand the disease.
This trial tests whether a special cell treatment can help stabilize a large abdominal aortic aneurysm (AAA) instead of just watching it grow. You may qualify if your aneurysm is at least 5 cm wide and you are scheduled for standard endovascular repair.
Hear when a new Mutations Affecting the COL5A Gene trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.