Testing empasiprubart with efgartigimod for myasthenia gravis
Treatments studied
Part of Brain & nervous system, Cancer, Immune system & allergy clinical trials.
This study adds a new drug called empasiprubart to the existing treatment efgartigimod for people with generalized myasthenia gravis (gMG) who have antibodies against acetylcholine receptors (AChR-Ab) and have only partially responded to efgartigimod. The goal is to see if the combination improves daily living more than efgartigimod alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a confirmed diagnosis of generalized myasthenia gravis (gMG).
- You must have antibodies against acetylcholine receptors (AChR-Ab positive).
- Your gMG must be class II, III, IVa, or IVb on the MGFA scale (mild to severe weakness).
- You must be currently taking efgartigimod and have had a partial response (improvement of less than 2 points on the MG-ADL scale).
- You need to have received vaccines for certain bacteria (meningitis and pneumonia) within the last 5 years, or be willing to get them at least 14 days before starting study drugs.
- You cannot have lupus, complement deficiency, or have recently used certain other complement inhibitors (like zilucoplan, eculizumab, or ravulizumab).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a new drug called empasiprubart for people with generalized myasthenia gravis (gMG) who have a certain antibody (AChR-Ab). It is given as a monthly IV infusion (into a vein) and aims to improve muscle weakness and daily functioning.
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