Clin2
NCT07293260Possibly a fitRecruiting

Olpasiran heart scan study for high Lp(a) patients

Cardiovascular Disease

Part of Heart & circulation clinical trials.

This study tests if a medication called olpasiran can lower a type of fat in your blood called Lp(a), which is linked to heart problems. You take the medicine or a placebo and get a special heart scan to see changes in your arteries.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
406 people
Ages
35 years to 80 years
Study type
Interventional

Who can take part

  • You must be between 35 and 80 years old.
  • You must have a blood test showing Lp(a) level of 200 nmol/L or higher.
  • You must have a heart scan showing plaque in at least one major artery.
  • You must have had a heart attack (type 1) or a procedure (like a stent) to open a blocked artery.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07136012Recruiting· Phase 3
Olpasiran trial to lower Lp(a) and prevent first heart attack or stroke

This trial tests if olpasiran can lower a type of cholesterol called Lp(a) to help prevent a first major heart attack, stroke, or other heart problems. It is for people at higher risk due to risk factors or early signs of artery disease, but who have not yet had a heart attack or stroke.

Alexander City, Alabama
NCT06496243Recruiting· Phase 2
Testing new drugs to lower Lp(a) cholesterol

This study tests two new drugs, alone and together, to lower a type of cholesterol called Lp(a) that increases heart disease risk. You may qualify if you have high Lp(a) and your LDL cholesterol is still high despite current treatment.

Philadelphia, Pennsylvania
NCT07613294Recruiting· Phase 3
Testing lepodisiran to reduce heart plaque buildup

This study tests whether a new medicine called lepodisiran can shrink plaque in heart arteries for adults with high Lp(a) (a type of cholesterol linked to heart disease) who have had a heart event or are at serious risk. The trial uses CT scans to monitor changes in your arteries.

La Jolla, California
NCT07079267AVAILABLE
Olpasiran early access program

This program provides early access to a study drug called olpasiran, which may help lower cholesterol. Doctors can request it for patients who have no other treatment options and cannot join a clinical trial.

NCT06995183Recruiting
Heart CT scan for relatives with high or low Lp(a)

This study uses a heart CT scan to look for early signs of heart disease in first-degree relatives of people with high or low Lp(a). It aims to find hidden risks before symptoms start.

Amsterdam, North Holland
NCT07767513Not yet recruiting· Phase 2
Oral medication for high lp(a) and heart risk

This study tests an oral medication called HRS-5346 to see if it can lower a type of fat in the blood called lipoprotein(a), which is linked to heart disease. If you have high Lp(a) and are at risk for heart problems, this trial may help reduce that risk.

Chengdu, Sichuan

Hear when a new Cardiovascular Disease trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.