Radiation, chemotherapy, and immunotherapy for advanced rectal cancer
Part of Cancer, Digestive system clinical trials.
This study tests a combination of radiation therapy, chemotherapy drugs (capecitabine and oxaliplatin), and two types of immunotherapy (a PD-1 blocker and IL-2) for locally advanced rectal cancer. The goal is to see if this combination helps shrink tumors and improve outcomes before surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 18–70 years old
- Rectal cancer confirmed by biopsy, located within 12 cm of the anus
- Cancer is advanced (stage T3–T4 or has spread to lymph nodes) but not spread to distant organs
- Good overall health and blood counts, liver, and kidney function
- No previous chemotherapy or immunotherapy for rectal cancer
- No active autoimmune disease, serious lung disease, or uncontrolled diabetes/high blood pressure
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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