Testing HRS-7249 and SHR-1918 for severe high triglycerides at risk of pancreatitis
Part of Hormones & metabolism clinical trials.
This trial tests two experimental drugs, HRS-7249 and SHR-1918, to lower very high triglyceride levels in people who are at high risk for pancreatitis. It aims to see if these drugs can reduce the risk of pancreatitis attacks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old but under 80 years old.
- You have severe high triglycerides and a high risk of pancreatitis.
- You have not had acute pancreatitis in the last 4 weeks.
- You do not have recent heart problems, like heart attack or stroke, in the last 3 months.
- Your kidney and liver function must be within certain limits (checked by blood tests).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a new medication called SHR-1918 for people with high cholesterol who are already on statins. The goal is to see if it can further lower cholesterol and improve health.
This trial tests an experimental drug called CS-121 for people with very high triglyceride levels that don't improve with standard treatments. It uses a new gene-editing approach to lower triglycerides and aims to reduce the risk of pancreatitis and other complications.
This trial tests a new medicine, SHR-1918, for people whose bad cholesterol (LDL-C) stays high even when they take statins and another type of cholesterol-lowering drug called a PCSK9 inhibitor. It aims to see if this additional treatment can lower their cholesterol more effectively.
This trial tests an investigational injection called SYH2070 to lower cholesterol and triglycerides in people who are already on a stable statin therapy. It may be a new option for those with mixed hyperlipidemia who need additional lipid control.
This trial tests a new medication, SHR-1918, to lower high triglyceride levels. It may be an option for people with moderately elevated triglycerides and controlled cholesterol.
This trial tests a new injectable drug called DR10624 for people with very high triglyceride levels. It aims to lower triglycerides and reduce the risk of pancreatitis (inflammation of the pancreas).
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