CAR T-cell therapy for autoimmune diseases
Treatments studied
Part of Heart & circulation, Immune system & allergy, Skin clinical trials.
This trial tests a special type of cell therapy (CAR T-cells) that targets two markers on immune cells, CD19 and BCMA, to calm overactive immune systems in people with certain autoimmune diseases. It's for those whose disease has not been controlled by standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have one of these autoimmune diseases that hasn't responded to or has returned after standard treatments: lupus, systemic sclerosis, inflammatory myopathy, ANCA-associated vasculitis, or connective tissue disease with low platelets.
- Your disease is active and meets specific severity scores (like lupus activity score of 8 or more, or vasculitis activity score of 15 or more).
- Your major organs (kidneys, liver, bone marrow) are working reasonably well, and you don't have serious infections, heart problems, or recent cancer.
- You are willing to use effective birth control or not become pregnant during the study and for 6 months after.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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