Universal CAR-T cell therapy for hard-to-treat autoimmune diseases
Treatments studied
Part of Bones, joints & muscles, Brain & nervous system, Eyes & vision, Heart & circulation, Immune system & allergy, Mouth & dental, Skin clinical trials.
This trial is testing a new type of cell therapy called universal CAR-T cells combined with immunosuppressant drugs for people with hard-to-treat autoimmune diseases. The goal is to see if this approach is safe and can help reduce disease activity.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You weigh more than 40 kilograms (about 88 pounds).
- You have a type of autoimmune disease that has not improved with standard treatments for over 6 months, or it has come back after being controlled.
- You are currently taking a stable dose of at least one standard treatment, like steroids or an immunosuppressant, and are willing to stop certain other immunosuppressants before the infusion.
- You have not had CAR-T therapy before.
- If you have cancer (other than B-cell lymphoma), you are not eligible.
- You do not have serious active infections like HIV, hepatitis B or C, or active tuberculosis.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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