Universal CAR-T cells plus immune drugs for resistant autoimmune diseases
Treatments studied
Part of Bones, joints & muscles, Brain & nervous system, Eyes & vision, Heart & circulation, Immune system & allergy, Mouth & dental, Skin clinical trials.
This trial tests a new type of 'universal' CAR-T cell therapy (made from donor cells) combined with immune-suppressing drugs for people with severe autoimmune diseases that haven't responded to standard treatments. The goal is to see if this approach can control the immune system and reduce disease activity.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You weigh more than 40 kilograms (about 88 pounds).
- You have a hard-to-treat autoimmune disease that hasn't gotten better after at least 6 months of standard treatments like steroids, methotrexate, or rituximab.
- You have an active form of lupus, Sjögren's syndrome, systemic sclerosis, inflammatory myositis, or ANCA vasculitis that meets specific disease activity scores.
- You are willing to use birth control during the study and for 6 months after, if you or your partner could become pregnant.
- You have not had CAR-T cell therapy before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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