Clin2
NCT07321847Possibly a fitNot yet recruiting

Studying an immune-boosting injection with liver ablation for colorectal cancer that has spread to the liver

Colorectal Cancer (CRC)Colon Cancer Liver MetastasesRectal CancerRectal Cancer With Liver MetastasesColorectal Liver Metastasis (CRLM)

Part of Cancer, Digestive system clinical trials.

This trial combines a standard tumor-removal procedure (ablation) with an investigational drug injected into the liver to see if it helps your immune system fight the cancer. It is for people whose colorectal cancer has spread only to the liver and who are having all visible liver tumors treated with ablation.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2/Phase 3
Enrollment
717 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • Your colorectal cancer has spread only to the liver (up to 5 tumors, each 3 cm or smaller).
  • You are going to have all liver tumors removed using a heat-based procedure (ablation), and you have no other cancer outside the liver.
  • You have had no more than 2 lines of previous systemic therapy for metastatic colorectal cancer.
  • You are in generally good health (able to care for yourself, but not necessarily able to work).
  • Your liver, kidney, and blood functions are within acceptable ranges, and you are not on certain blood thinners.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06053996Not yet recruiting
Radiation and immunotherapy for colorectal cancer that has spread

This trial tests combining focused radiation (SBRT) with immunotherapy for colorectal cancer that has spread to the liver or lungs. The goal is to see if this combination can shrink tumors and improve control of the cancer.

Ramat Gan
NCT06630624Recruiting· Phase 1/Phase 2
IP-001 with ablation for colorectal liver metastases

This trial tests whether adding the drug IP-001 to tumor ablation (microwave or irreversible electroporation) helps control colorectal cancer that has spread to the liver. The goal is to find the best dose and see how the immune system responds.

Amsterdam, North Holland
NCT06526338Recruiting· Phase 2
Study treatment after liver surgery or microwave ablation for liver cancer

This study tests an investigational drug called IP-001 given after surgery or microwave ablation for liver cancer. The goal is to help prevent the cancer from coming back.

Louisville, Kentucky
NCT06590259Recruiting· Phase 2
Ablation plus drug therapy for colorectal cancer liver metastases

This trial tests a combination treatment that uses heat or cold (ablation) to destroy liver tumors along with medicines that boost your immune system to fight cancer. It is for people whose colorectal cancer has spread to the liver and who could not have surgery, or whose first treatment stopped working.

Shanghai
NCT07381309Not yet recruiting· Phase 2
Combination therapy for colorectal cancer that has spread to the liver

This trial tests a combination of treatments for people with colorectal cancer that has spread to the liver and cannot be removed by surgery. It uses an oncolytic virus (which infects and kills cancer cells) along with radiation, chemotherapy, targeted therapy, and immunotherapy to try to shrink the liver tumors.

Guangzhou, Guangdong
NCT04062721Not yet recruiting· Phase 1
Immune system support after radiofrequency for liver tumors

This trial tests a treatment to boost the immune system after a procedure called radiofrequency ablation (RFA) that uses heat to destroy liver tumors. It is for people with colorectal cancer that has spread to the liver but not elsewhere, and aims to see if this can improve outcomes.

Boulogne-Billancourt

Hear when a new Colorectal Cancer (CRC) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.