Clin2
NCT07333937Possibly a fitNot yet recruiting

Neratinib, fulvestrant, and eribulin for advanced breast cancer

Brest Cancer

Part of Cancer clinical trials.

This trial tests a combination of three drugs for advanced breast cancer that is both hormone-receptor-positive and HER2-positive, and has stopped responding to a newer targeted therapy called T-DXd. The goal is to see if this new combo can shrink tumors or slow their growth.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
35 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are a woman aged 18 to 75.
  • You have advanced breast cancer that is hormone-receptor-positive and HER2-positive.
  • Your cancer has gotten worse or you could not tolerate prior treatment with T-DXd.
  • You have had prior treatment with anthracycline and taxane chemotherapy.
  • You have at least one measurable tumor, and your overall health is good enough (able to do light activity).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07520760Recruiting· Phase 2
Eribulin Plus Anlotinib for HER2-Negative Breast Cancer

This trial tests a combination of two cancer drugs (eribulin and anlotinib) for women whose breast cancer has spread and stopped responding to previous treatments, particularly antibody-drug conjugates. The study aims to see if this combination can help slow or shrink the cancer.

Guangzhou
NCT05933395Recruiting· Phase 2
Targeted treatment for ER+ breast cancer after CDK4/6 therapy

This Phase 2 study tests a genetically guided treatment plan for ER-positive breast cancer that has progressed after CDK4/6 therapy. It may help by matching treatment to tumor genetic changes.

Lebanon, New Hampshire
NCT07480694Not yet recruiting
Eribulin for advanced HER2-negative breast cancer after ADC treatment

This trial is testing a drug called eribulin (given alone or with other drugs) for people with advanced HER2-negative breast cancer that has already been treated with an ADC (antibody-drug conjugate). The goal is to see if this new treatment can help control the cancer and potentially shrink tumors.

NCT07498478Recruiting· Phase 2
Tinengotinib and fulvestrant for advanced HR+ HER2- breast cancer

This trial tests a new drug called tinengotinib combined with the hormone therapy fulvestrant for people with HR-positive, HER2-negative breast cancer that has come back or spread. It is for those who have already tried a CDK4/6 inhibitor and at least one hormone therapy.

Guangzhou, Guangdong
NCT06734533Recruiting
Anlotinib combo for HR+ breast cancer that has spread

This trial tests a combination treatment including anlotinib for women with hormone receptor-positive breast cancer that has spread to other parts of the body and has stopped responding to standard therapies. It is for those who have already tried a CDK4/6 inhibitor and endocrine therapy.

Changsha, Hunan
NCT07330544Recruiting· Phase 2
Study of entinostat with anlotinib or fulvestrant for advanced breast cancer

This trial tests adding entinostat (a drug that may help hormone therapy work better) to anlotinib or fulvestrant for people with HR-positive, HER2-negative advanced breast cancer that has worsened after prior hormone therapy and a CDK4/6 inhibitor. It aims to find a new treatment option for those who cannot use chemotherapy yet.

Zhejiang, Hangzhou

Hear when a new Brest Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.