Study of entinostat with anlotinib or fulvestrant for advanced breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests adding entinostat (a drug that may help hormone therapy work better) to anlotinib or fulvestrant for people with HR-positive, HER2-negative advanced breast cancer that has worsened after prior hormone therapy and a CDK4/6 inhibitor. It aims to find a new treatment option for those who cannot use chemotherapy yet.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a woman aged 18 or older.
- Your breast cancer is hormone receptor (HR)-positive and HER2-negative (specific test results confirm this).
- Your cancer has spread or come back after at least one prior hormone therapy and a CDK4/6 inhibitor (like Ibrance).
- You have not had chemotherapy or an antibody-drug conjugate (ADC) for advanced disease.
- You have at least one tumor that can be measured on scans (by RECIST 1.1 rules).
- You do not have active brain metastases or cancer spread to the lining of the brain and spinal cord (leptomeningeal disease).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new combination of two targeted drugs (entinostat and pyrotinib) with hormone therapy for people with advanced, triple-positive breast cancer whose disease has progressed after trastuzumab (Herceptin). The goal is to see if this approach works better than current options.
This trial tests a combination of two drugs, entinostat and a pill form of paclitaxel, for people with a type of advanced breast cancer that is hormone receptor-positive and HER2-negative. It may be an option if you have already tried several treatments, including hormone therapy with a CDK4/6 inhibitor and a chemotherapy with paclitaxel.
This trial tests a new drug called tinengotinib combined with the hormone therapy fulvestrant for people with HR-positive, HER2-negative breast cancer that has come back or spread. It is for those who have already tried a CDK4/6 inhibitor and at least one hormone therapy.
This trial tests a new study medicine (PF-07248144) combined with fulvestrant in people with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has worsened after previous treatments. It may be an option if you've already tried a CDK4/6 inhibitor and endocrine therapy.
This Phase 2 study compares a combination medicine (lenvatinib plus letrozole) against fulvestrant to treat metastatic estrogen-receptor positive, HER2-negative breast cancer after the cancer has grown despite hormone therapy plus a CDK4/6 inhibitor. It may help by finding a more effective treatment option after your first lines have stopped working.
This trial tests a new oral drug, BTX-9341, for people with advanced or metastatic hormone receptor-positive, HER2-negative breast cancer who have already had certain treatments, including a CDK4/6 inhibitor. The goal is to see if it is safe and effective.
Hear when a new Breast cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.