Does acetylcysteine protect hearing during cisplatin chemo?
Part of Brain & nervous system, Ear, nose & throat, Injuries & trauma clinical trials.
This trial tests if taking N-acetylcysteine (NAC) can help prevent hearing loss caused by high-dose cisplatin chemotherapy. If you're getting cisplatin and are between 18 and 70, you may be able to join.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You will receive high-dose cisplatin (more than 200 mg/m2 total and at least 50 mg/m2 per dose).
- You have not taken N-acetylcysteine (NAC) in the last 2 weeks.
- You have not taken certain other drugs that can harm hearing (like specific antibiotics, diuretics, or high-dose aspirin) in the last 2 weeks.
- You are not being treated for nasopharyngeal cancer (cancer at the back of the nose/throat).
- You have not had radiation to your head/neck that exposed your inner ear to high doses.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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