Testing NB-4746 for people with ALS
Part of Brain & nervous system, Hormones & metabolism clinical trials.
This study tests an investigational drug called NB-4746 for people with ALS. The goal is to see if it can slow the progression of the disease. It is for people diagnosed within the last couple of years who are still able to eat and breathe on their own.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have a confirmed diagnosis of ALS (Lou Gehrig's disease).
- Your first ALS symptoms started less than 2 years ago (for Phase 2) or less than 4 years ago (for Phase 1).
- You can eat and drink by mouth without a feeding tube.
- You have a breathing test showing your lung function is at least 60% of normal.
- You are not using a ventilator or breathing machine most of the day.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests an experimental drug called ALN-SOD for people with ALS caused by a specific genetic mutation in the SOD1 gene. The goal is to see if it is safe and can help slow the disease.
This study tests an investigational oral medication, FHND1002, for people with ALS whose disease has been progressing for less than 2 years. It aims to slow further decline in muscle function and breathing ability.
This pilot trial tests whether a dietary supplement called HMB (beta-hydroxy-beta-methylbutyrate) can help lower a protein called IGFBP7 that may be linked to ALS progression. If it works, this approach might slow down muscle weakness in people with ALS.
This trial tests a new drug called XT-150 for ALS. The goal is to see if it is safe and how the body handles it. It may be an option if you have had ALS symptoms for up to 3 years and have good enough lung function.
This study tests a supplement called acetyl-L-carnitine (ALCAR) to see if it can slow the progression of ALS. It is for people in the early stages of the disease who are already taking riluzole and have good lung and muscle function.
This study tests an experimental drug called PLL001 for people with ALS. It aims to see if the drug is safe and if it can slow the progression of the disease. You may be a good fit if you have been recently diagnosed and are still in the early stages of ALS.
Hear when a new Amyotrophic Lateral Sclerosis (ALS) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.