Esketamine with or without talk therapy for tough depression
Treatments studied
Part of Mental health clinical trials.
This trial tests if adding a type of talk therapy called integration therapy helps esketamine work better for people with depression that hasn't improved with other treatments. You'll receive esketamine, and some people also get guided sessions to reflect on their experiences.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 21 and 65 years old.
- You have major depression that hasn't gotten better after trying at least two different antidepressants.
- Your depression symptoms are severe, as measured by a standard questionnaire.
- You are willing to use effective birth control if you could become pregnant.
- You can attend all study visits and are ready to do reflective exercises before and after the medicine.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests esketamine nasal spray (a fast-acting antidepressant) for people with treatment-resistant depression who haven't gotten better after trying at least two other antidepressants. It looks at how well the spray works in everyday doctor's offices, not just in research clinics.
This trial is testing whether a combination of ketamine and talk therapy can help people with depression that hasn't responded to other treatments. You will receive ketamine in a safe, supervised setting while working with a therapist.
This study tests if intravenous ketamine can help people with treatment-resistant depression who haven't found relief from at least two other treatments. If you qualify, you'll receive ketamine infusions to see if it improves your mood.
This study tests whether adding coaching sessions can help people who are already getting ketamine or esketamine treatment for depression that hasn't responded to other medications. You'd receive weekly coaching calls designed to support your recovery while you continue your regular ketamine clinic visits.
This study tests whether esketamine, a nasal spray for depression, can help adults whose depression has not improved with at least two other antidepressants. Participants continue their current treatment while receiving esketamine.
This trial tests how treatment with esketamine affects metabolism in people with depression. It may help if you have not responded to at least two standard antidepressants.
Hear when a new Treatment-resistant Depression (TRD) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.