Sac-TMT plus immunotherapy before surgery for triple-negative breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This study tests a combination of two drugs—Sacituzumab Tirumotecan (Sac-TMT) and an immunotherapy called KL-A167—given before surgery to shrink triple-negative breast tumors. It aims to improve outcomes for people with early-stage, high-risk breast cancer who have not yet had any treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 65 years old.
- You must have triple-negative breast cancer (no hormone receptors or too much HER2) that is at least 2 cm and may have spread to nearby lymph nodes, but not to distant organs.
- You cannot have received any prior treatment (chemotherapy, targeted therapy, or radiation) for this breast cancer.
- You must be willing to provide a tumor tissue sample for testing.
- You need to have normal heart, blood, kidney, and liver function (your doctor will check this).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a combination of an immunotherapy drug (QL1706) plus standard chemotherapy given before surgery to shrink triple-negative breast cancer. The goal is to see if this approach helps remove the tumor more completely.
This clinical trial tests a new drug called Sacituzumab Tirumotecan given before surgery to women with an aggressive type of early-stage breast cancer (triple-negative breast cancer, or TNBC). The goal is to see if it can improve treatment outcomes.
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