Cooling vs normal temperature after tough-to-stop seizures
Part of Brain & nervous system clinical trials.
This trial tests whether lowering body temperature (targeted hypothermia) can help people recover better after a severe seizure that doesn't stop with usual medicines, compared to keeping body temperature normal. It's for adults on a breathing machine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You are having a seizure that won't stop or keeps coming back without waking up in between.
- At least two seizure medicines have not stopped the seizure.
- You are on a breathing machine (mechanical ventilation).
- The seizure started no more than 3.5 hours ago.
- You or a family member agree to join this study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 trial tests a medication strategy to stop “refractory status epilepticus,” a severe seizure condition that can happen after a cardiac arrest. It may help by reducing ongoing seizure activity after return of circulation in the ICU.
This trial is for adults in the intensive care unit who are having seizures that last at least 5 minutes or keep coming back without fully recovering. It tests a study approach for managing a dangerous seizure emergency and may help doctors improve care for critically ill patients.
This trial studies whether using EEG (a brain-wave test) in the ICU can help guide care for people whose seizures keep going despite initial medicines. It may benefit patients with severe, difficult-to-stop status epilepticus by improving how doctors find and treat ongoing seizure activity.
This study looks at how people recover after a prolonged seizure (status epilepticus) in the intensive care unit. It tests thinking and memory skills, and may include a follow-up MRI, to learn more about the brain's healing process.
This trial tests whether taking ketone esters (a special form of ketones) can help stop refractory generalized convulsive status epilepticus (a seizure emergency that is hard to control). If you qualify, the study team will check safety closely, especially your breathing, heart stability, and blood sugar/acid levels.
This trial tests if adding ketamine to standard care can stop seizures that continue after a first treatment. It is for people having a convulsive seizure lasting more than 5 minutes and who are still seizing in the emergency room.
Hear when a new Status Epilepticus trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.