Clin2
NCT07393477Possibly a fitNot yet recruiting

New drug combo before surgery for head and neck cancer

Head and Neck Squamous Cell CarcinomaHead and Neck Squamous Cell Carcinoma HNSCC

Part of Cancer clinical trials.

This trial tests a new combination of two drugs (one targeted therapy and one immunotherapy) plus standard chemotherapy before surgery for head and neck cancer. The goal is to see if this approach can shrink tumors and improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
30 people
Ages
18 years to 70 years
Study type
Interventional

Who can take part

  • Age 18 to 70 years old
  • Has squamous cell carcinoma of the oral cavity, oropharynx, larynx, or hypopharynx that is stage III or IVA
  • Have not received any prior anti-cancer treatment for this disease
  • Good physical condition (able to care for yourself and do light activities)
  • Able to have standard surgery plus any needed radiation or chemotherapy afterward
  • No active autoimmune disease or other major illnesses

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07589049Not yet recruiting· Phase 2
Combination drug therapy before surgery for recurrent head and neck cancer

This trial is testing a combination of two drugs (becotatug vedotin and pucotenlimab) given before surgery to shrink recurrent head and neck cancer that has stopped responding to prior immunotherapy and chemotherapy. The goal is to see if this approach helps make the tumor removable and improves outcomes.

Foshan, Guangdong
NCT07381075Recruiting· Phase 2
New drug combo before surgery for head and neck cancer

This trial tests a new drug (antibody-drug conjugate) alone or with an immunotherapy drug before surgery for head and neck cancer that can be removed. The goal is to see if this combination shrinks the tumor and improves outcomes.

Chengdu, Sichuan
NCT07814287Recruiting· Phase 2
New drug combo for advanced EGFR-positive head and neck cancer

This trial tests a new combination of drugs for a type of head and neck cancer that has a specific protein called EGFR. The treatment combines an antibody-drug conjugate, an immunotherapy, and standard chemotherapy. The goal is to see if this combination shrinks or controls the cancer before possible surgery.

Guangzhou, Guangdong
NCT07683507Not yet recruiting· Phase 2
Combination drug study for head and neck cancer

This trial tests a new combination treatment for head and neck cancer. The treatment uses an investigational drug (becotatug vedotin) with an immunotherapy (a checkpoint inhibitor). The goal is to see if this combination can shrink tumors or slow cancer growth.

NCT07677475Not yet recruiting· Phase 2
Immunotherapy before surgery for advanced head and neck cancer

This trial tests whether combining two immunotherapy drugs before surgery is better than one alone for advanced head and neck cancer. The goal is to see if the combination can shrink tumors more and improve outcomes.

Dongguan, Guangdong
NCT07586124Recruiting· Phase 2
Immunotherapy plus antibody drug for advanced head and neck cancer

This trial tests a combination of two drugs (pucotenlimab and becotatug vedotin) given before surgery for advanced head and neck squamous cell carcinoma. The goal is to shrink tumors and improve outcomes when combined with surgery.

Beijing, Beijing Municipality

Hear when a new Head and Neck Squamous Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.