Clin2
NCT07677475Possibly a fitNot yet recruiting

Immunotherapy before surgery for advanced head and neck cancer

Head and Neck Squamous Cell Carcinoma

Treatments studied

Part of Cancer clinical trials.

This trial tests whether combining two immunotherapy drugs before surgery is better than one alone for advanced head and neck cancer. The goal is to see if the combination can shrink tumors more and improve outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
65 people
Ages
18 years to 70 years
Study type
Interventional

Who can take part

  • You have a type of head and neck cancer called squamous cell carcinoma that is advanced but can still be removed with surgery.
  • Your cancer must test positive for a protein called PD-L1.
  • You have not had any previous treatment for this cancer, such as radiation, chemotherapy, or immunotherapy.
  • You are between 18 and 70 years old.
  • You are generally healthy and able to care for yourself (ECOG score 0 or 1).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07589049Not yet recruiting· Phase 2
Combination drug therapy before surgery for recurrent head and neck cancer

This trial is testing a combination of two drugs (becotatug vedotin and pucotenlimab) given before surgery to shrink recurrent head and neck cancer that has stopped responding to prior immunotherapy and chemotherapy. The goal is to see if this approach helps make the tumor removable and improves outcomes.

Foshan, Guangdong
NCT04807140Recruiting· Phase 2
Study of toripalimab before surgery for head and neck cancer

This trial tests toripalimab (an immunotherapy) given before surgery for untreated head and neck squamous cell carcinoma, either alone or with chemotherapy. The goal is to shrink or control the cancer earlier and see if it improves outcomes for people who plan curative surgery.

Guangzhou, Guangdong
NCT06016413Not yet recruiting· Phase 2
Immunotherapy plus chemotherapy before surgery for head and neck cancer

This trial tests a new immunotherapy drug (adelbelimab) combined with chemotherapy given before surgery, for people with head and neck cancer. The goal is to see if this combination can shrink the tumor and improve the chances of successful surgery.

Guangzhou, Guangdong
NCT07393477Not yet recruiting· Phase 2
New drug combo before surgery for head and neck cancer

This trial tests a new combination of two drugs (one targeted therapy and one immunotherapy) plus standard chemotherapy before surgery for head and neck cancer. The goal is to see if this approach can shrink tumors and improve outcomes.

Hangzhou, Zhejiang
NCT05993858Not yet recruiting· Phase 2
Immune therapy and targeted therapy before surgery for head and neck cancer

This trial tests giving a combination of two drugs (an immunotherapy drug called a PD-1 inhibitor and a targeted therapy called cetuximab) before surgery to shrink head and neck cancers. The goal is to see if this approach lowers the chance of the cancer coming back after surgery.

Wuhan, Hebei
NCT07381075Recruiting· Phase 2
New drug combo before surgery for head and neck cancer

This trial tests a new drug (antibody-drug conjugate) alone or with an immunotherapy drug before surgery for head and neck cancer that can be removed. The goal is to see if this combination shrinks the tumor and improves outcomes.

Chengdu, Sichuan

Hear when a new Head and Neck Squamous Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.