Device therapy for restless legs with medication worsening
Part of Brain & nervous system, Mental health clinical trials.
This study tests a device that sends mild electrical pulses to nerves in your lower legs to calm RLS symptoms, especially at night. It is for people whose RLS has worsened despite taking dopamine-agonist medications.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have been diagnosed with Restless Legs Syndrome (RLS).
- Your RLS is moderate to severe (score 15 or higher on a standard RLS rating scale).
- You have been told that your RLS symptoms have gotten worse because of your dopamine-agonist medication (this is called 'augmentation').
- You are currently taking a stable dose of a dopamine-agonist drug (like pramipexole or ropinirole) for at least 4 weeks, and the daily dose is at least the equivalent of 25 mg of levodopa.
- You have RLS symptoms at night that wake you up at least 3 nights a week, and the symptoms are mostly in your lower legs or feet.
- You are not pregnant, do not have certain medical conditions (like advanced kidney disease, iron deficiency anemia, severe heart disease, or epilepsy), and are not taking certain medications that can make RLS worse.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at brain connections related to body awareness in people with restless legs syndrome (RLS). It may help researchers understand RLS better.
This study looks at how active the nerves are in people with Willis-Ekbom disease (restless legs syndrome) and compares them with people without it. It may help researchers understand what drives symptoms and how the condition works in the body.
This study uses frequent, brief check-ins (often by phone) to better understand restless legs syndrome symptoms in daily life. It may help researchers learn patterns of symptoms that could improve future care plans.
This trial studies how a single session of exercise changes blood markers in people with restless legs syndrome (RLS) who are not currently being treated. If you have moderate to severe RLS and are not regularly active, this study may help us understand how exercise affects your condition.
This trial tests whether the steroid prednisone can help people whose Restless Legs Syndrome has stopped responding to usual treatments. If you have tried first-line RLS medications without success and your symptoms are still severe, this study may offer a new option.
This study tests whether a small implanted device that sends electrical signals to the spinal cord can help people with severe restless leg syndrome (RLS) who haven't improved with medications. RLS causes uncomfortable sensations in the legs, especially at night, and this treatment may provide relief when standard drugs don't work.
Hear when a new Restless Legs Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.