Clinical trials
Restless Legs Syndrome clinical trials
Below are recruiting restless legs syndrome clinical trials, each written for real people, not researchers. We’re tracking 24 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05044520Recruiting
Study of what restless legs feels like
This study looks at the different symptoms and experiences people have with restless legs syndrome. It may help researchers better understand the condition so care can improve for patients.
MontpellierAges 18 years+ - NCT05695963Recruiting
Daily phone check-ins for restless legs symptoms
This study uses frequent, brief check-ins (often by phone) to better understand restless legs syndrome symptoms in daily life. It may help researchers learn patterns of symptoms that could improve future care plans.
BordeauxAges 18–70 - NCT06481176Recruiting
How exercise affects blood in restless legs syndrome
This trial studies how a single session of exercise changes blood markers in people with restless legs syndrome (RLS) who are not currently being treated. If you have moderate to severe RLS and are not regularly active, this study may help us understand how exercise affects your condition.
Stanford, CaliforniaAges 18 years+ - NCT06684782Recruiting
Restless leg syndrome in Thai Parkinson's patients
This trial is looking at how common restless leg syndrome is in people with Parkinson's disease in Thailand. It aims to better understand the link between the two conditions so doctors can improve care for people with both.
Bangkok, BangkokAges 18–80 - NCT06726785Recruiting
Gene changes in nasal cells of RLS patients on long-term dopamine agonist
This study looks at changes in a gene (DRD2) in nasal cells of people with Restless Legs Syndrome who are taking a dopamine agonist medication for a long time. It aims to understand how this gene might be involved in RLS.
San Francisco, CaliforniaAges 18–60 - NCT06747741Recruiting
Stretching vs. physical therapy for restless leg syndrome in seniors
This study compares a special stretching technique (PNF) with standard physical therapy to see which better relieves restless leg syndrome symptoms in people aged 60 and older. It may help reduce the uncomfortable urge to move your legs at night.
IslamabadAges 60 years+ - NCT06806891Recruiting
Walking meditation for restless legs in dialysis
This trial tests if Buddhist walking meditation can help restless leg syndrome in people on hemodialysis. If you have both conditions and are not obese, you may qualify.
Dokki, Giza GovernorateAges 35–65 - NCT06863740Recruiting
Cannabis for Restless Legs Syndrome
This study tests whether cannabis can help people with Restless Legs Syndrome that has not improved with standard treatments. If you have RLS and other treatments haven't worked well, you may be able to join.
Toronto, OntarioAges 25 years+ - NCT06918847Recruiting
Comparing myofascial release vs. cupping for restless leg and knee OA
This study compares two hands-on therapies – myofascial release (gentle stretching of connective tissue) and cupping (using suction cups on the skin) – to see which one better improves quality of life for people who have both restless leg syndrome and knee osteoarthritis. If you have both conditions, you may be able to join.
Karachi, SindhAges 40–70 - NCT07083492Recruiting
Detecting iron deficiency in pregnancy and after birth
This study uses a non-invasive test to check for iron deficiency in women during pregnancy and up to 3 months after giving birth. It aims to make detection easier and more comfortable for you.
Würzburg, BavariaAges 18 years+ - NCT07110961Recruiting
Heart rate test for restless legs diagnosis
This trial tests a new way to diagnose Restless Legs Syndrome (RLS) by looking at your heart rate changes during a simple leg movement test while you're in a sleep study. It may help doctors diagnose RLS more easily.
Bangkok, BangkokAges 18–70 - NCT07144631Recruiting
Nerve stimulation for restless legs in pregnancy
This trial tests if a small nerve stimulation device can safely and effectively reduce restless legs symptoms in pregnant people. If you are between 21 and 26 weeks pregnant with a confirmed diagnosis of restless legs syndrome (RLS), you may be eligible.
Providence, Rhode IslandAges 18 years+ - NCT07179406Recruiting
Spinal cord stimulators for restless leg syndrome
This study tests whether a spinal cord stimulator can help people with restless leg syndrome (RLS). It compares people with RLS to healthy volunteers to see if the device reduces symptoms.
Birmingham, AlabamaAges 18 years+ - NCT07199504RecruitingPhase 2/Phase 3
Dipyridamole for restless legs syndrome in dialysis patients
This trial tests if dipyridamole, a medication that affects blood flow, can help relieve restless legs syndrome (RLS) in people on hemodialysis. It may offer a new treatment option for RS related to kidney failure.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT07675109Recruiting
Extended therapy for restless legs syndrome
This study tests a device that delivers nerve stimulation to help with restless legs syndrome (RLS). It aims to see if using the device for a longer period each night can reduce RLS symptoms and improve sleep.
Pleasanton, CaliforniaAges 21 years+ - NCT07453862RecruitingPhase 1
New drug for restless legs syndrome: efficacy and safety study
This trial tests a new drug (a calcium channel modulator) to see how well it works and how safe it is for people with moderate to severe restless legs syndrome (RLS). It may offer a new treatment option for those with typical or variant RLS.
Beijing, Beijing MunicipalityAges 18–75 - NCT07628387Recruiting
Exercise Types for Restless Legs in Pregnancy
This study compares two types of exercise—aerobic (heart-pumping) and muscle relaxation—to help pregnant women with restless leg syndrome sleep better and feel less tired. Restless leg syndrome causes uncomfortable sensations in the legs, especially at night, which disrupts sleep during pregnancy.
Lahore, Punjab ProvinceAges 20–40 - NCT07642089Recruiting
Stretching and strength training for restless legs in pregnancy
This study tests whether gentle stretching and strength exercises can help pregnant women with restless leg syndrome—a condition that causes uncomfortable sensations in the legs and disrupts sleep. The goal is to see if these exercises reduce symptoms and improve sleep quality during pregnancy.
Lahore, Punjab ProvinceAges 18–35 - NCT03082755RecruitingPhase 4
Study sleep agitation and restless legs in Alzheimer’s patients
This trial studies treatment for troubling nighttime restlessness and agitation in people with Alzheimer’s disease. It may help improve sleep and nighttime comfort and reduce nighttime behavior problems.
Austin, TexasAges 55 years+ - NCT05321355Recruiting
Sleep disorder patient registry for narcolepsy and other conditions
This is a research registry that collects information from people with narcolepsy and other neurological sleep disorders. It may help doctors better understand sleep problems and improve future care.
Mainz, Rhineland-PalatinateAges 18–120 - NCT05908214Recruiting
Electrical stimulation for leg stiffness and overactive nerves
This study tests a treatment using high-frequency electrical stimulation to reduce overactive nerve signals that can cause stiff legs, poor ankle control, cramps, or restless legs. It may help improve movement and comfort during walking or at night, depending on the condition.
LausanneAges 18 years+ - NCT07001891Recruiting
Brain activity study for restless legs syndrome
This study looks at brain connections related to body awareness in people with restless legs syndrome (RLS). It may help researchers understand RLS better.
BordeauxAges 18–70 - NCT02929732Recruiting
Study muscle nerve activity in restless legs
This study looks at how active the nerves are in people with Willis-Ekbom disease (restless legs syndrome) and compares them with people without it. It may help researchers understand what drives symptoms and how the condition works in the body.
MontpellierAges 18–74 - NCT02670161Enrolling by invitationPhase 4
Using electronic records to improve care for brain and nerve conditions
This study looks at how doctors use electronic medical records to improve treatment and care for people with certain brain and nervous system conditions. It may help because it tests practice-based approaches across neurology visits.
Evanston, IllinoisAges 18–100
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Common questions
- Are there clinical trials for restless legs syndrome?
- Yes. Clin2 currently lists 24 recruiting restless legs syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a restless legs syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a restless legs syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.