Botox before hemorrhoid surgery to reduce pain after surgery
Treatments studied
Part of Digestive system, Heart & circulation, Pain clinical trials.
This trial tests whether injecting botulinum toxin (Botox) into the anal muscle before hemorrhoid removal surgery can lower pain after the operation. It is for people with advanced hemorrhoids that have not gotten better with other treatments and who are already planning to have surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have grade III or IV hemorrhoids that cause symptoms and have not improved with other treatments
- You are scheduled for open or closed hemorrhoidectomy surgery
- You are not allergic to botulinum toxin, human albumin, or local anesthetics
- You do not have a nerve or muscle disease like myasthenia gravis
- You have not used certain antibiotics or other medicines that affect nerve signals in the last 14 days
- You do not have bleeding problems or take blood thinners that cannot be temporarily stopped
- You do not have an active infection or inflammation in the anal area, including inflammatory bowel disease
- You have not had prior anal sphincter surgery or ongoing accidental bowel leakage
- You are not pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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