Botox before hemorrhoid surgery to reduce pain after surgery
Treatments studied
Part of Digestive system, Heart & circulation, Pain clinical trials.
This trial tests whether injecting botulinum toxin (Botox) into the anal muscle before hemorrhoid removal surgery can lower pain after the operation. It is for people with advanced hemorrhoids that have not gotten better with other treatments and who are already planning to have surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have grade III or IV hemorrhoids that cause symptoms and have not improved with other treatments
- You are scheduled for open or closed hemorrhoidectomy surgery
- You are not allergic to botulinum toxin, human albumin, or local anesthetics
- You do not have a nerve or muscle disease like myasthenia gravis
- You have not used certain antibiotics or other medicines that affect nerve signals in the last 14 days
- You do not have bleeding problems or take blood thinners that cannot be temporarily stopped
- You do not have an active infection or inflammation in the anal area, including inflammatory bowel disease
- You have not had prior anal sphincter surgery or ongoing accidental bowel leakage
- You are not pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether giving a nerve block (an injection that numbs the area around the buttock) before hemorrhoid surgery can reduce pain after the operation. If you're having this surgery, the nerve block may help you recover more comfortably with less need for strong painkillers.
This study tests whether a nerve block (an injection to numb the area) can reduce pain after outpatient hemorrhoid surgery. It may help you recover with less discomfort.
This study compares a lidocaine ointment versus a nitroglycerin (GTN) ointment for pain relief after hemorrhoid removal surgery. It aims to see which works better for patients with advanced hemorrhoids.
This trial compares two surgical techniques for hemorrhoids to see which one causes less pain and tenesmus after the operation. It aims to help patients recover more comfortably.
This study tests a numbing injection near the tailbone to reduce pain after hemorrhoid surgery. It may help you need fewer pain medications and recover more comfortably.
This trial tests whether ketamine can lessen pain after hemorrhoidectomy (surgery for severe hemorrhoids). It may help reduce how much pain medicine you need during recovery.
Hear when a new Hemorrhoids trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.