Zanidatamab before surgery for HER2 positive colon or rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests if the drug zanidatamab, given before surgery, can help treat colon or rectal cancer that has a specific marker called HER2. The goal is to see if this approach can shrink tumors and improve outcomes for people whose cancer has not spread to other parts of the body.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have colon or rectal cancer that can be removed with surgery and your doctor plans to treat it with a goal of cure.
- Your cancer has a high level of a protein called HER2 (tested on a biopsy sample).
- Your cancer does not have changes in a gene called RAS (wildtype means no mutation).
- You are at least 18 years old.
- You are in generally good health, able to care for yourself (ECOG score 0-2).
- You have adequate kidney, liver, and heart function as shown by blood tests and an echocardiogram (heart ultrasound).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a drug called zanidatamab in people with certain cancers (endometrial, colorectal, head & neck, non-small cell lung, or sarcoma) that have a specific change in the HER2 gene. It's for those whose cancer has spread or can't be removed and who have tried at least one prior treatment.
This trial tests a new targeted drug called zanidatamab given with standard chemotherapy before surgery for HER2-positive stomach or gastroesophageal junction cancer. It aims to shrink the tumor enough to allow successful removal, either for cancers that were initially too advanced for surgery or for those with high-risk features.
This trial tests a new drug called zanidatamab combined with standard chemotherapy before surgery for HER2-positive stomach or gastroesophageal junction cancer. It aims to shrink the tumor and improve outcomes.
This study tests zanidatamab, a new drug designed to target HER2-positive cancers that have progressed despite prior treatment. It's for patients with advanced solid tumors of certain types (like endometrial, bladder, pancreatic, or colorectal cancer) whose tumors have a specific genetic marker called HER2 that makes them candidates for this therapy.
This trial tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein (called HER2-positive). It aims to see if zanidatamab can shrink or slow the growth of these tumors.
This trial tests adding zanidatamab (an antibody targeting HER2) to standard chemotherapy before and after surgery for operable HER2-positive stomach or esophagus cancer. It aims to see if this combination improves outcomes.
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