Brain stimulation to improve movement in hereditary spastic paraplegia
Part of Brain & nervous system, Genetic & congenital clinical trials.
This study tests whether a non-invasive brain stimulation technique (called neuromodulation) can improve walking, balance, and other movements in adults with hereditary spastic paraplegia (HSP). It may be a good fit if you can walk with or without help, have stable spasticity medications, and don't have a pacemaker or epilepsy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a diagnosis of hereditary spastic paraplegia (HSP) – genetic confirmation is helpful but not required.
- You can walk at least 10 meters with or without a walker, cane, or other aid, OR if you use a wheelchair, you can do seated mobility tasks and transfers.
- Your medications for spasticity (like baclofen, tizanidine, or Botox) have been the same for at least 4 weeks and you don't plan to change them during the study.
- You don't have an implanted device like a pacemaker or deep brain stimulator, and you don't have epilepsy, recent leg surgery, or other conditions like multiple sclerosis that affect walking.
- You are able to understand English, give informed consent, and come to study visits with or without assistance.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if robot-assisted walking therapy can help people with hereditary spastic paraplegia (a condition causing progressive leg stiffness and weakness) improve their walking ability. It may be an option if you can walk indoors on your own.
This study tests a combined exercise program with flexibility, strength, aerobic, and movement training to see if it helps improve walking in adults with Hereditary Spastic Paraplegia. Participants attend at least 10 supervised sessions over several weeks.
This trial uses a noninvasive neuromodulation approach to stimulate the spinal walking circuits in children after spinal cord injury. It is meant to see whether the treatment can help a child practice stepping when they currently cannot stand or start walking.
This study tests whether a noninvasive electrical stimulation applied to the outside of the body, paired with physical therapy, can improve movement and walking for people with neurologic conditions. You may be asked to complete regular therapy sessions and simple movement tasks while the team measures your progress.
This trial studies whether a non-surgical electrical treatment to the spinal area can improve walking and leg control after a stroke. It’s for people who have had a single stroke and still need hands-on support to walk.
This study tests whether non-invasive electrical stimulation of the spinal cord, combined with physical therapy, can improve your ability to stand and walk after a spinal cord injury. It explores how your brain and spinal cord can adapt and rebuild connections to help you move better.
Hear when a new Hereditary Spastic Paraplegia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.